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Hyaluronic acid (or hyaluronan) is found in highest concentrations in the fluids of the eyes and joints, and in the skin.
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Introduction
Hyaluronic acid (or hyaluronan) is found in highest concentrations in the fluids of the eyes and joints, and in the skin. Hyaluronan is in the glycosaminoglycan family along with chondroitin and glucosamine, and works by acting as a cushion and lubricant in the joints and other tissues. On average, a 70 kg (154 lb) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day. Hyaluronan is an important component of articular cartilage, where it is present as a coat around each cell (chondrocyte).When cartilage proteins bind to hyaluronan in the presence of a link protein, large, highly negatively charged aggregates form. These aggregates retain water and are responsible for the resilience of cartilage (its resistance to compression).
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